Biochemistry Products

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INTENDED USE 
TYDAL is a Widal slide and tube agglutination test that detects the presence the serum agglutinins (O, H) in the patient’s serum, with typhoid and paratyphoid fever.

SUMMARY
Enteric fever occurs when pathogenic microorganisms like S. typhi, S. paratyphi A, S. paratyphi B, S. paratyphi C infect the human body. During the course of disease, the body responds to this antigenic stimulus by producing antibodies whose titre rises slowly in early stages, to a maxima and then slowly falls till it is undetectable. Antibodies to Salmonella organisms may be detected in the patient serum from the second week after onset of infection. Information regarding the titres and whether or not they are rising or falling can be obtained by ® performing serological tests using TYDAL antigen suspensions. Usually tube titres of 1:80 and above are taken as diagnostically significant, however for endemic areas higher cut-offs may need to be established.

REAGENT
TYDAL contains ready to use concentrated, smooth antigen suspensions of the bacilli; S. typhi 'O', S. typhi 'H', S. paratyphi 'AO', S. paratyphi 'BO', S. paratyphi 'AH', S. paratyphi 'BH', S. paratyphi 'CH', S. paratyphi 'CO' and / or polyspecific positive control reactive with these antigens. Each batch of reagents undergoes rigorous quality control at various stages of manufacture for its specificity and performance.

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CLINICAL SIGNIFICANCE
Increased serum calcium may be observed in hyperparathyroidism, vitamin D intoxication, multiple myeloma and some neoplastic diseases of bone. Decreased serum calcium may be observed in hypoparathyroidism, vitamin D deficiency, steatorrhea, nephrosis, and nephritis. 

PRINCIPLE
At a neutral pH, the Ca²+ forms with arsenazo lll a complex, the color intensity of which is directly proportional to the concentration of calcium in the sample. 

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SUMMARY
Rickettisae is an arthropod associated infection of ticks, mites, lice, or fleas. The disease is frequently associated with vertebrates; including humans as accidental hosts. Rickettsia conorii causes Mediterranean Spotted Fever in humans and is contracted by contact with infected brown dog ticks. Other Rickettsia include Rickettsia prowazekii, which causes typhus, Rickettsia rickettsii, which causes Rocky Mountain Spotted Fever and Rickettsia akari, which causes rickettsialpox. PROGEN OXK, PROGEN OX19, PROGEN OX2 antigen suspensions are employed for the Weil-Felix test. The Weil-Felix test is based on the principle that some strains of Proteus share common somatic constituents with certain species ofRickettsia. Sera from patients infected withRickettsia will therefore produce agglutination withProteus antigen suspensions. PROGEN antigen suspensions employed in the Weil-Felix test are used for diagnosis of Rickettsial infection and differential diagnosis in patients with Febrile fever. Antigen suspension of Proteus OX19 antigen suspension reacts strongly with sera of patients with typhus group rickettsiae and rocky mountain spotted fever. Proteus OX2 reacts strongly with sera of patients with spotted fever infections, while the Proteus OXK antigen suspension reacts strongly with sera of patients infected with scrub typhus.

REAGENT
PROGENOXK / PROGENOX19 / PROGENOX2 reagents contain ready to use standardized, killed, stained, smooth specific antigen suspensions of Proteus OXK/OX19/OX2.

PRINCIPLE
The smooth, killed stained PROGENantigen suspensions are mixed with the patient's serum.Antibodies produced due to rickettsial infection if present in the patient serum will react with the stained PROGEN antigen suspension to produce an agglutination reaction. No agglutination indicates the absence of Rickettsial antibodies.

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Turbilatex Method's ASO 

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• Packaging Details: 50 ml.

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SUMMARY
Tuberculosis occurs worldwide and is rampant in many countries. Though curable, its infection is on the rise. The most specific test is the positive bacterial culture of a patient's sputum sample. This is cumbersome and time consuming. X-rays, smears for AFB and Tuberculin tests though comparatively rapid are not conclusive. Adenosine Deaminase (ADA) is an enzyme widely distributed in mammalian tissues, particularly in T Lymphocytes. Increased levels of ADA are found in various forms of tuberculosis making it a marker for the same. Though ADA is also increased in various infectious diseases like Infectious Mononucleosis, Typhoid, Viral Hepatitis, initial stages of HIV, and in cases of malignant tumours, the same can be ruled out clinically

PRINCIPLE
Adenosine Deaminase hydrolyses adenosine to ammonia and inosine. The ammonia formed further reacts with a phenol and hypochlorite in an alkaline medium to form a blue indophenol complex with sodium nitroprusside acting as a catalyst. Intensity of the blue coloured indophenol complex formed is directly proportional to the amount of ADApresent in the sample.

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Summary

Iron found in blood is mainly present in the hemoglobin of the RBC's. It's role in the body is mainly in the transportation of oxygen and cellular oxidation. Iron is absorbed in the small intestine, and bound toa globulin in the plasma, called transferrin,and transported to the bone marrow for the formation of hemoglobin. Increased serum levels are found in hemolytic anemias, hepatitis, lead and iron poisoning. Decreased serum levels are found in anemias caused by iron deficency due toinsufficientintakeor absorption of iron, chronic blood loss, late pregnancy and cancer. Increase in TIBC is found in Iron defecient anemias and pregnancy. Decrease in TIBC is found in hypoproteinemia, hemolytic / pernicious / sicklecell anemias, inflammatory diseases and cirrhosis.

Principal 

Iron, bound to Transferrin, is released in an acidic medium and the Ferric ions are reduced to Ferrous ions. The Fe(II) ions react with Ferrozine to form a violet coloured complex. Intensityofthecomplexformed isdirectlyproportionaltothe amount of Iron presentinthesample. For TIBC, the serum is treated with excess of Fe (II) to saturate the iron binding sites on transferrin. The excess Fe (II) is adsorbed and precipitated and the Iron content in the supernatant is measured to give the TIBC.

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• Packaging Details: Pack size = 35 ml.

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ERYSCREEN reagent combipack consists of monoclonal blood grouping Anti-A, Anti-B, Anti-D. 

It is used for Blood grouping in laboratories

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• Packaging Details: 3x12 ml.

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Progen Ox-2 Antigen for Well Felix Test
What is Progen OX2?PROGEN OX19, PROGEN OX2, PROGEN OXK antigen suspensions are employed for the Weil-Felix test. The Weil-Felix. test is based on the principle that some strains of Proteusshare common somatic constituents with certain species of Rickettsia.

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• Packaging Details: 5 ml.

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For the Determination of Adenosine Deaminase Activity in Serum, Plasma and Biological Fluids by Enzymatic Method

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• Packaging Details: 10 ml.

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Albumin & Total Protein Bcg Biuret Method

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• Packaging Details: 1 Box

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Pathozyme Diagnostics is a high-tech company specializes in manufacturing of Clinical Chemistry, Serology reagents, Stain & Indicators, Stain Kits

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• Delivery Time: 1-2 Days
• Packaging Details: 50 Tests.

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Liquid rabbit brain thromboplastin reagent for PT determination Preservative : 0.01% Thimerosal 

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• Packaging Details: 12 x 5 ml.

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Progen OX-K Antigen for Welfilix TestWhat is Progen OX2?PROGEN OX19, PROGEN OX2, PROGEN OXK antigen suspensions are employed for the Weil-Felix test. The Weil-Felix. test is based on the principle that some strains of Proteusshare common somatic constituents with certain species of Rickettsia.

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• Packaging Details: VOLUME - 5 ml.

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CREATININE-J

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• Packaging Details: 2x150 ml.

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Drabkin′s reagent is used in measuring haemoglobin from blood samples. It comprises potassium ferricyanide, potassium cyanide and potassium dihydrogen phosphate as components. Potassium ferricyanide oxidizes haemoglobin to methemoglobin and then to cyanmethemoglobin. The cyanmethemoglobin levels is estimated at 530nm.

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• Delivery Time: 1-2 Days
• Packaging Details: VOLUME - 1 lit.

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 Drabkin's solution for hemoglobin estimation can be made in the laboratory. There are commercially ready-made kits are available.

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• Delivery Time: 1-2 DAYS.
• Packaging Details: BRAND - PATHOZYME DIAGNOSTICS VOLUME - 5 Lit.

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α-Amylase is an enzyme that hydrolyses α bonds of large, α-linked polysaccharides, such as starch and glycogen, yielding shorter chains thereof, dextrins, and maltose

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• Packaging Details: 10 Test

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This reagent kit is intended for "In Vitro" quantitative determination of Alkaline Phosphatase activity in serum/plasma. CLINICAL SIGNIFICANCE: Elevated levels

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• Packaging Details: 2x25 ml.

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Haemostasis Reagent P.T. for Determination 

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• Packaging Details: 5 ml.

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Triglyceride Liquid Base - Parameter of  Biochemistry 

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• Packaging Details: 100 ml.

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ADA (Enzymatic Kinetic Method)

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• Packaging Details: BRAND - Pathozyme Diagnostics Volume - 1 X 15 ml.

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Rapid Immunochromatographic Assay for the detection of IgM antibodies to HEV in human Serum/Plasma

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• Packaging Details: 10 Tests

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Urea Liquid

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• Delivery Time: 1-2 Days
• Packaging Details: 100 + 25 ml.

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Magic Reticulin Stain Kit 

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• Packaging Details: 50 Tests